Released on: August 7, 2008, 3:55 pm

Press Release Author: AnaSpec Inc.

Industry: Biotech

Press Release Summary: Matrix metalloproteinases (MMPs) belong to a family of
secreted or membrane-associated proteins capable of digesting extracellular matrix
components. The importance of MMPs in tumor development and invasion as well as
other diseases is well known.

Press Release Body: August 7, 2008 - San Jose, CA

Matrix metalloproteinases (MMPs) belong to a family of secreted or
membrane-associated proteins capable of digesting extracellular matrix components.
The importance of MMPs in tumor development and invasion as well as other diseases
is well known.

AnaSpec has introduced the SensoLyteTM 570 Generic MMP Assay Kit, offering the
industry's highest emission wavelength for MMP detection. The higher emission
wavelength allows the SensoLyteTM 570 Generic MMP Assay Kit to offer greater
sensitivity in detecting enzyme activities with minimal interference from the
autofluorescence of cell components and test compounds. This kit is ideal for
detecting generic MMP activity in biological samples or for high throughput
screening of MMP inducers and inhibitors using purified MMPs.

The SensoLyteT 570 Generic MMP Assay Kit is optimized to detect the activity of a
variety of MMPs, including MMP-1, 2, 7, 8, 9, 10, 13, and 14 (Fig.1). This kit uses
a FRET peptide substrate labeled with 5-TAMRA (fluorophore) and QXLT 570 (quencher)
for continuous measurement of enzyme activities. In an intact FRET peptide, the
fluorescence of 5-TAMRA is quenched by QXLT 570. Upon the cleavage of the FRET
peptide by MMPs, the fluorescence of 5-TAMRA is recovered, and can be continuously
monitored at excitation/emission = 540 nm/575 nm. The assays are performed in a
convenient 96-well format.

Company Info

AnaSpec is a leading provider of integrated proteomics solutions to the world's
largest biotech, pharmaceutical, and academic research institutions. With a vision
for innovation through synergy, AnaSpec focuses on three core technologies:
peptides, detection reagents (including dyes, assay kits, and antibodies) and
combinatorial chemistry.

Visit www.anaspec.com for more information.



Web Site: http://www.anaspec.com

Contact Details: AnaSpec Inc.
2149 O\'Toole Ave.
San Jose, CA 95131
1-408-452-5055 (Tel)
1-408-452-5059 (Fax)
1-800-452-5530
ping@anaspec.com
www.anaspec.com